Category: Andrew Maynard

Three ways synthetic biology could annihilate Zika and other mosquito-borne diseases

In just a few short weeks, Zika has shot from being an obscure infection to a headline-hitting public health disaster. The virus is spreading rapidly across the Americas (and potentially beyond), is suspected of being associated with birth defects that affect brain development and currently has no specific vaccine or treatment. Understandably, scientists are scrambling to respond to what the World Health Organization is now calling a “Public Health Emergency of International Concern.” In the arsenal of weapons against the mosquito-borne disease, there are tried and tested approaches that include the liberal application of insecticides and repellents, widespread use of mosquito nets and elimination of breeding sites. Yet to combat Zika and other mosquito-borne disease, more is needed. Which is why scientists are increasingly turning to emerging technologies such as synthetic biology for solutions. The joke goes that if you get 10 synthetic biologists in a room together, you’ll get 10 different explanations of what they do. After all, synthetic biology is a young and rapidly evolving field. But underneath this lack of clarity lies a clear and profound shift in our technological capabilities – the ability to “upload” genetic code to computers, edit and manipulate it, and then “download” it into living organisms. In effect, we’ve discovered how to hack biology – how to code in DNA and computer-design living things. It’s early days yet – biology is complex and messy and doesn’t follow the same rules as computer code. But increasingly, scientists are learning how to use synthetic biology to change how organisms operate – including insects that carry dangerous human diseases, such as Zika. Aedes aegypti mosquitoes carry Zika, dengue and chikungunya. Paulo Whitaker Turn off a gene and goodbye mosquitoes Using synthetic biology-based genetic engineering techniques, the British company Oxitec (owned by U.S.-based Intrexon Corp) has

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Can citizen science empower disenfranchised communities

Early in 2015, a group calling itself the Nappy Science Gang hit the parenting scene in the U.K. It was made up of moms and dads who used cloth nappies – or diapers – with their kids, and wanted to know the best ways to keep them clean and safe. The Nappy Science Gang is part of a growing global movement toward citizens getting involved in science. Over the past few years, there’s been an explosion of opportunities for ordinary people to collect data for researchers, and sometimes help analyze it. Platforms such as Zooniverse, Scientific American and SciStarter are all helping citizens (anyone who’s part of a community, in this context) connect with scientists and get involved with the process of scientific discovery. Without doubt, the movement is enabling more people than ever before to become engaged in science and to contribute toward scientific progress. Yet in many of these citizen science projects, researchers remain firmly in the driver’s seat – asking the questions, setting the agenda and making sense of the data. They’re big on engagement, maybe not so much on empowerment – especially when it comes to issues that directly affect participants’ lives. Citizens setting the science agenda This is where the Nappy Science Gang is different. It represents an emerging trend where citizens partner with experts to do the science that’s useful to them and their community, not just someone else. Partnerships like this can have wide-reaching consequences. One question asked by the Nappy Science Gang, for instance, was: why are biological detergents not advisable for washing cloth diapers? Despite this being the advice given by organizations like the U.K. National Health Service, the group’s research findings didn’t seem to support it. So they asked one of their expert advisers for help. Unable to explain things,

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Technology innovation and life in the 21st century Views from Civil Society

In 2009, I commissioned ten guest articles on technology innovation from people working for, associated with or generally reflecting the views of Civil Society groups. Over six years on, these essays still present insightful and often challenging views on technology innovation, and are well worth a revisit. The aim was to expose readers to perspectives on technology innovation that are sometimes drowned out in mainstream conversations, and to give a sense of the breadth of opinions and perspectives that are often lumped under the banners of “civic society” or “Non Government Organizations.” You may not agree with everything that’s written (I’d be surprised and disappointed if you were).  But whether you are a tech believer, a tech skeptic, or somewhere in between, I hope these articles will inform, challenge, surprise, and even amuse you. Biopolitics for the 21st Century Marcy Darnovsky, Center for Genetics & Society Innovation for whom? Innovation for what? The Impact of Ableism Gregor Wolbring, University of Calgary Beyond safety: some bigger questions about new technologies Georgia Miller, Friends of the Earth Innovation for a well-fed world – what role for technology? Geoff Tansey, Food Ethics Council Stop and Think: A Luddite Perspective Jen Sass, Natural Resource Defense Council (NRDC) A new era of responsible innovation Richard Owen, University of Westminster Ecology and Nanotechnology Richard Worthington, Loka Reversing the Technological Dilemma George Kimbrell, International Center for Technology Assessment (ICTA) Innovation in the Doc Tim Jackson, University of Surrey 21st Century Tech Governance? What would Ned Ludd do? Jim Thomas, ETC Group

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What will it take to master the fourth industrial revolution

In April 2000, Bill Joy famously wrote in Wired Magazine: Our most powerful 21st-century technologies – robotics, genetic engineering, and nanotech – are threatening to make humans an endangered species. At the time, Joy was an accomplished technologist and chief scientist at Sun Microsystems. Yet he argued passionately that society was in danger of being destroyed by the very technologies scientists and engineers thought could save it. Nearly 16 years on, Klaus Schwab, founder of the World Economic Forum (WEF), has just published an equally passionate treatise on the power of emerging technologies. Unlike Joy, he maps out a vastly more optimistic future where technology innovation – and our ability to harness it – becomes a powerhouse for social and economic growth. Technology as a revolutionizing force for good Klaus Schwab founded the World Economic Forum in 1971 to ‘improve the state of the world.’ World Economic Forum, CC BY-NC-SA In his new book The Fourth Industrial Revolution – published to coincide with the WEF annual meeting in Davos – Schwab argues that we are at the beginning of a technological revolution that “is fundamentally changing the way we live, work, and relate to one another.” At the heart of Schwab’s revolution is an accelerating convergence between our increasingly powerful technological capabilities. Autonomous vehicles, 3D printing, gene editing, robotics, artificial intelligence, the Internet of Things – these and many more emerging trends, he suggests, are arising from an unparalleled melding of physical, biological and digital worlds. These coalescing capabilities are both transforming and being transformed by society. And it is this tight coupling that, to Schwab, signals a new era of technology innovation. Just as the widespread use of steam, electricity and computers have in the past revolutionized society, so, he argues, will this new wave of technological convergence. Are

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What if we approach risk like entrepreneurs approach innovation

If you’ve been following this month’s Consumer Electronics Show (CES), you’ll know with absolute certainty that the future is cool, shiny and stuffed to the brim with “must-have” gadgets. Reading the ebullient reports, you’d be hard-pressed to find anything other than overflowing optimism for how technology will transform our lives. And admittedly, it’s hard to imagine how smart shoes or a rollable TV screen could possibly be bad for us. From virtual reality so “there” you can almost touch it, to the Internet of every imaginable thing, we’re being dazzled by the seemingly infinite possibilities that modern tech has to offer. But I wonder whether, in all the buzz and hype, we’re in danger of losing sight of the darker side of technology innovation. CES and similar expos represent the glitzy face of deeper trends that could be destructive if developed without a sophisticated appreciation of potential risks. All technologies come with risks With the uncritical enthusiasm around CES, it’s easy to ignore the potential consequences of irresponsible technology innovation. It’s even easier to turn a blind eye to the challenges we face in developing technologies that are good for society as a whole, and don’t just enrich those who create them. Take for example robotics, artificial intelligence (AI) and the Internet of Things (IoT) – three trends that were amply represented at the show. While each holds the potential to profoundly change our lives for the better, these technologies are by no stretch of the imagination intrinsically safe. Fears over the consequences of irresponsible AI development have already been widely voiced, and the rapid rise of the Internet of Things threatens to make everyday objects vulnerable to cyber attacks. And all three have the potential to widen the gap between the privileged and the disadvantaged. In today’s evolving social

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Steampunk smart pill

It’s that time of year again when technology pundits peer into their crystal balls, and predict the hottest tech trends of the coming twelve months. Let’s be honest though, these lists can get a little stale. So I thought I’d break ranks this year by imagining what a top tech trends list would look like in a “steampunk” world, where steam engines, clockwork mechanisms, and retro-artistic flair, rule supreme.

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ASU Refugee Education Fund

The School for the Future of Innovation in Society aa Arizona State University (ASU) has created a new fund to support refugees whose undergraduate or graduate education has been disrupted because of their circumstances – please give generously.

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If Elon Musk is a Luddite, count me in

On December 21, the company SpaceX made history by successfully launching a rocket and returning it to a safe landing on Earth. It’s also the day that SpaceX founder Elon Musk was nominated for a Luddite Award. It’s an odd juxtaposition, to say the least.

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Hoverboards and health - how good for you is this year’s hottest trend 750x400 2

Walking across campus to my office each morning this semester, I’ve found it hard to ignore the growing number of students using hoverboards to get around. These two-wheel self-balancing boards (they don’t really hover, Back-to-the-Future-style) are one of the hottest gadgets this holiday season. As sedentary lifestyles continue to be a major underlying factor in chronic conditions like type 2 diabetes and heart disease, I wondered whether these trendy two-wheelers are simply another way to avoid the exercise we all need to stay healthy. As it turns out, it’s not only their health that hoverboard users need to worry about.

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Cancer - Countering the bad luck hypothesis

A new study has just been published in the journal Nature that calls the so-called “bad luck hypothesis”of cancer formation into question, and concludes that cancer risk is heavily influenced by external factors.

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Are vegetarian diets really more harmful to the environment

Carnegie Mellon University had an eye-catching headline on its news feed this morning: Eat More Bacon. It was based on a new study that suggests fruit and veg have a higher environmental impact per calorie than meat. However, the analysis failst to take account of the nutritional needs in a healthy diet.

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the real risk from consumer drones this holiday season

This holiday season, the Federal Aviation Administration (FAA) is estimating that over one million small “Unmanned Aerial Systems” (sUAS’s) – drones, to the rest of us – will be sold to consumers. But as hordes of novice pilots take to the air, just how safe are these small bundles of metal, plastic, video cameras and whirling blades?

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Gene Drives

Gene editing and gene drives are rapidly emerging as the disruptive technologies du jour.  But what are they, what can they do, and why should you care? Just last week, research was published that took us a step closer to being able to re-engineer whole species by driving specific genes through successive generations   – the species in this case was mosquitoes, and the trait to be engineered was the ability to host malaria-causing parasites. And this week, The U.S. National Academy of Sciences, together with the U.S. National Academy of Medicine, the Chinese Academy of Sciences, and the U.K.’s Royal Society, are co-hosting an international summit on gene editing in humans – and especially the ethical and governance issues emerging capabilities raise. To help make sense of gene drives and the underlying gene editing technologies, there’s a new explainer video on Risk Bites.  Watch the video here, or read the transcript below. Transcript Imagine we could stop mosquitoes from carrying malaria. For good.  Or prevent ticks from transmitting lyme disease. Or eliminate the billions of dollars of damage caused by bugs to our food supplies each year. Gene drives are a radical new approach to genetic engineering that could help us achieve these goals, and a whole lot more.  Yet, as you might expect, the technology isn’t risk-free. Gene drives are designed to eliminate unwanted traits in insects and other animals.  They work by pushing out genetic modifications through whole species, until eventually, every critter has been changed into something we’ve intentionally engineered. The idea isn’t especially new.  But it’s only very recently that advanced gene editing techniques have made human-designed gene drives possible.  And at the heart of this revolution is a new technique for precision-editing genes – clustered regularly interspaced short palindromic repeats, or if you’re not into brain-bending tongue twisters, CRISPR for short.

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Rethinking Twitter

A few weeks ago, I decided to take a bit of a vacation from Twitter.  I wanted some time to chew over my frustrations over the emerging Twitter culture, and get my head around whether I wanted to be a part of this community, and if so, how to best to participate and engage. While I suspect hardly anyone noticed my absence, I did miss Twitter  – maybe not surprisingly as I’ve been hanging out on the platform for several years now. Not hanging out on Twitter, I found myself less connected to what’s going on, and I missed being able to talk about and engage on things that grabbed my interest. At the same time, taking a break from the snark, gossip and social pressure that pervades Twitter felt really good. As a result I’ve decided to make some changes in how I use Twitter as I end the “vacation” – something I should probably have done some time ago. Here’s what I ended up with: Tweeting Tweet about cool stuff around science, technology, and society Tweet about interesting stuff your colleagues, students and friends are doing Tweet about your own work – but not too much Tweet about random stuff that interests and intrigues you, and makes you smile Retweet tweets about cool stuff around science, technology, and society Retweet tweets about random stuff that interests and intrigues you, and makes you smile Retweet generously tweets from colleagues, students, friends, and followers   Twitter Behavior Treat others with respect Engage generously Promote civil dialog Promote a culture of collegiality, inclusiveness, and engagement Don’t tweet or retweet critical or potentially hurtful comments about individuals Don’t get involved in twitter shaming Don’t block people unless they are extremely and consistently offensive Don’t be an ass If you are an ass, fix it!   Following others Follow people who engage positively with you Follow

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Are you breathing carbon nanotubes and should you be worried

For over two decades, carbon nanotubes have been attracting attention.  First, they were seen as a super-strong, super-conductive new form of carbon that could potentially revolutionize everything from space travel to drug delivery.  Later, concerns were raised that these long, thin, fiber-like materials might cause or exacerbate lung diseases if inhaled. Now, a new study in the journal EBioMedicine has suggested that these microscopic carbon fibers are ubiquitous in the air many of us breathe every day.  And the obvious question that results is: should you be worried? The new paper – a collaboration between scientists in Paris in France, and Texas in the US – analyzed carbon particles found in lung fluid samples from 64 asthmatic children living in Paris.  Using high resolution Transmission Electron Microscopy (TEM), they found carbon nanotube-like fibers in each sample.  Similar fibers were found in lung cells from five patients, and dust samples taken from deposits around vehicle tailpipes, and inside buildings close to minor roads. The authors concluded that carbon nanotube are the main component of inhaled particulate matter. At first blush, the paper seems alarming – carbon nanotubes that could be harmful were found in the lungs of children with a lung condition.  However – as the authors acknowledge in the paper – the results, while interesting, don’t provide evidence that these exposures are a health risk. To start with, it wasn’t too surprising that some fibrous carbon-based particle were found in the samples.  Research over the past ten years has indicated that carbon nanotube-like particles are incidentally formed as a by-product in a number of high temperature processes.  In 2006 for instance, Murr and Guerrero found multiwalled carbon nanotubes in soot collected from burning pine wood.  And in 2013, Jung and colleagues found carbon nanotubes amongst diesel exhaust particles under controlled

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Benjamin Franklin and his ipad #3 750x400

Why do people read science blogs? Surprisingly, we don’t have a good answer to this.  There’s a vibrant online community of people blogging about science, and talking about blogging about science, and blogging about blogging and talking about science.  But we don’t know that much about the people that science blogs and bloggers set out to serve. This is a problem from a science communication perspective, because if we don’t know who we’re engaging, and why they’re engaged, it’s very difficult to communicate effectively. To address this rather vital knowledge gap, Dr. Paige Jarreau – one of the foremost researchers on science blogging – has a plan.  Working with 60 bloggers, she will be conducting a large-scale survey of science blog readers to map out who reads these blogs, and why. To my knowledge, it’ll be the largest systematic survey of it’s type, and will provide extremely valuable insights into the effectiveness of science blogging as a way of communicating and engaging on science with non-expert audiences, as well as indicating how science blogging can become an even more effective communication platform.  However, there is a catch. Research costs money, and this project is no exception.  Rather brilliantly though, Paige is raising some of the money needed for the study through crowdfunding. What excites me about this is that it gives the online science community the chance to have skin in the game.  It enables community members to demonstrate their support for, and dedication to, the effective communication of science through blogs.  And it enables the data collection and analysis that will help them better-achieve their science communication aims. And of course, being a science-based community, they understand the importance of data and evidence in guiding decisions and actions, so there’s a rather elegant symmetry to them supporting the work that will generate the data that helps them in their work.

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New-report-on-sustainable-hydraulic-fracking

Back in 2011 – while I was Director of the University of Michigan Risk Science Center – I was part of a larger team exploring the possibility of conducting a full-blown assessment of hydraulic fracturing (fracking) possibilities and pitfalls in Michigan.  We were interested in applying the Integrated Assessment methodology developed at the University of Michigan to a growing challenge – the sustainable development and use of fracking. Four years later, the final report from the resulting program on high volume hydraulic fracturing in Michigan has just been published. This represents three intensive years of research and analysis by University of Michigan experts in evaluating fracking options across multiple dimensions, and developing options for proceeding sustainably. While the report focuses on Michigan, the analysis is broadly applicable to other states and beyond, and provides a deep and broad analysis of fracking. The program  set out to explore the best environmental, economic, social, and technological approaches for managing hydraulic fracturing in the State of Michigan.  Today’s final report presents options for moving forward sustainably that cover public participation in decision making, use of water resources, chemicals use policies.  It also provides a comprehensive introduction to fracking, and the challenges and opportunities it presents. Complimenting the final report are seven technical reports that address the technology of fracking; the geological/hydrological context of fracking; environment and ecology considerations; public health issues, policy and law aspects of fracking; the economics of fracking; and public perception around fracking. Together with today’s report, these provide an exceptionally comprehensive overview of the multidimensional challenges presented by fracking, and the options available to develop sustainable uses of the technology. While I’m no longer at Michigan, I’m proud that the Risk Science Center and its members were able to contribute support and expertise to this initiative, as part of helping enable informed decisions on risk within society. Feature image: Process of

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Microbeads the science behind the risk

There’s a new viewpoint article in the Journal Environmental Science and Technology that calls for a ban on the use of microbeads, based on available evidence, and that has been causing something of a stir. The authors argue that the number of microbeads being washed into the environment from personal care products raises sufficient concerns to justify replacing them with alternative materials, or removing them from products altogether. These small beads of plastic – usually polyethylene – are added to many personal care products products like facial scrubs, shampoos, and even toothpaste – as an exfoliant.  The problem is, they are designed to wash down the sink, where they get into environmental water systems.  And because they don’t degrade, they accumulate, and eventually enter the food chain. More worryingly, they have a tendency to adsorb toxic materials such as dioxins – making them even more worrisome. Totally serendipitously, the latest video from Risk Bites takes a look at the science behind microbead risks. – worth watching as a quick and understandable primer on the issue. The video was made in collaboration with Ana Sophia Knauf, who is the author of a new series on cosmetics, health and the environment on Grist.org.  It also had valuable input from Professor Sherri (Sam) Mason at the State University of New York at Fredonioa – a leading expert on microbead contamination. One comment from Sam that isn’t highlighted particularly in the video – but is important – is that microbeads are just one segment of the growing issue of microplastics in bodies of water.  These millimeter-sized fragments of plastic are what becomes of the masses of plastic products we discard into the environment and that make their way into our rivers, lakes and oceans.  Sam pointed out that, because these fragments are often odd sizes, they have

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Reporters- don't do this to scientists

Update 9:47  PM Sept 17.  It turns out that the reporter at the Sydney Morning Herald didn’t receive the three emails I sent on the 15th, and therefore did not realize that I had responded.  We have since exchanged emails, and the SMH article has updated to remove the statement that I wasn’t available for comment.  Bottom line – if things get messy, reporters, please do do this, and thanks to SMH and the article’s writer for responding positively.   Effective science reporting depends on a relationship of trust between journalists and scientists. Breach that trust, and effective reporting and science communication suffer. Journalists need to know they can call on scientists to provide accurate, understandable, and often rapid, information on topics.  Scientists need to know their help and input will be used with respect and honesty.  Without trust on both sides, things get messy fast. This morning, my name appeared in the Sydney Morning Herald.  But not against a quote or as a source. Instead, this is what I read: “Fairfax Media contacted … leading risk expert Professor Andrew Maynard at the University of Michigan. They were not available for comment.” Where an organization or person is being held accountable for their actions in an article, it’s sometimes necessary to state when they weren’t available for comment – it establishes due diligence on the reporter’s end, and makes a strong statement abut the stance and attitude of the organization/person under scrutiny. Experts who are approached for further insight, context, or background information on a piece are different. Scientists work with reporters for a number of reasons.  Most often though, they do so because of a personal and professional sense of responsibility to help people understand their worlds through the lens of science. If, as a reporter, you call out a scientist for not commenting on something, you erode the implicit relationship

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For tech innovation to succeed, we need parallel innovation in how we think about risk

In October 2014, Google announced it was working on an innovative nanotechnology-based approach to avoiding and managing disease. The idea was to create a pill that would deliver magnetic, functionalized nanoparticles from the gut to the bloodstream. Once there, they would circulate — presumably for days, or longer — picking up biomarkers of disease along the way. The particles would then be remotely interrogated directly by the patient, perhaps using a wrist-mounted monitor. In effect, the plan was to create the ultimate in wearable tech: a personal device that could give you up-to-the-minute information on health and wellness, much as wrist-worn devices provide feedback on fitness today. Google’s nanosensor concept is certainly audacious. Its success though will depend on overcoming a number of challenges — not least, addressing potential risks. Based on what is currently known about nanoparticle behaviour, the technology faces a plethora of possible health and environmental challenges. Failure to address these could leave the company with a non-starter on its hands. Yet the probability of causing harm is not the only risk that could prevent these nanosensors from becoming a reality. In the expanded list of potential risks, there is also the chance of outmoded or overly restrictive regulations blocking progress; or the possibility of investor ambivalence, consumer suspicion, or social media backlash. These hint at a much larger and murkier risk landscape that emerging technologies will have to navigate to be successful. Google’s nanoparticle sensors are indicative of a growing number of technologies that are facing increasingly complex risk-related challenges. Recently, the Future of Life Institute awarded close to US$7 million for research aimed at ensuring the robust and beneficial development of artificial intelligence — funding prompted by how unexpected risks could undermine the technology’s development. Earlier this year, published research into using the gene-editing technique

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2020 Science is published by Andrew Maynard - Director of the Risk Innovation Lab at Arizona State University. More ... 

Andrew can be found on Twitter at @2020science and on YouTube at Risk Bites

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