2020 Science » Biohackers

Synthetic biology, ethics and the hacker culture

Andrew Maynard — Tue, 17 Aug 2010 09:00:53 +0000

While the DIY Biotechnology community has grown considerably since this post, the piece still captures something of what is still a young movement, and one that challenges assumptions about top-down technology innovation.

Originally posted June 13 2008

Read Thomas L. Friedman’s “The World is Flat” or Neal Stephenson’s “Cryptonomicon”, and you get a glimpse into how the hacker culture that emerged at the tail end of the twentieth century revolutionized the digital world. Will a confluence of emerging technologies—including information tech, biotech, and nanotech—lead to a similar revolution in the biological world?

Behind every computer screen is a complexity of software and hardware that together create a virtual world in which many of us spend more time living out our lives than is probably healthy—whether crunching numbers, playing games or churning out our latest blog. This world is built in part (some would say a large part) on the work of technically savvy individuals—hackers—who have learned the art of manipulating the fundamental building blocks of the digital world.

According to that fount of all knowledge Wikipedia, a “computer hacker is a person who enjoys designing software and building programs with a sense for aesthetics and playful cleverness.” A big attraction of hacking is the ability to change “reality” (albeit a digital reality) by manipulating the software (and hardware in the broadest interpretation of “hacker”) that defines it. And the factors that make this possible? Easy access to knowledge and tools, and the development of global grassroots networks for information sharing.

But here’s a question: what are the chances of a biology-based hacker culture arising; enticed by the lure of tinkering with biological codes that define living systems, rather than digital codes that govern digital systems? The answer is that it is already here. The “biohacking” culture is alive and kicking, and already pushing the boundaries of what is possible and acceptable.

Reading through a just-released report on the social and ethical challenges of synthetic biology commissioned by the U.K. Biotechnology and Biological Sciences Research Council (Synthetic Biology. Social and Ethical Challenges. PDF, 740 KB), I was particularly intrigued by a short section on what has been termed “garage biology.” (For a succinct overview of the report , I would recommend Richard Jones’ recent blog entry at Soft Machines.) On the subject of garage biology, authors Andrew Balmer and Paul Martin of the Institute for Science and Society at the University of Nottingham had this to say:

“As DNA sequencing becomes cheaper and quicker and second hand equipment becomes available on eBay the power to create synthetic sequences may be dispersed to many individuals and groups. Biohackers have also become known by the portmanteau ‘biopunk’ (biotech punk), that has its origins as a science fiction genre. The most recent, and significant addition to this movement has been the online publication of a ‘Primer for Synthetic Biology’, a manual, written in simple, non-technical language, for those wishing to engage themselves in some bio hacking.”

With my interest piqued, I went on-line to check out the “biopunk” community. A quick search brought up this recent comment from a teenager on the biopunk.org website:

“A few weeks ago I had somebody in school complaining about her eating disorder, Ceiliacs disease or something, and how she can’t eaten certain foods because of it. She has mentioned this before, and frankly I was tired of it, so I spent just *20* minutes on the internet during my lunch period and found a cure hidden in the patent database, and then told her how to use http://e-oligos.com/ and thenhttp://biohack.sf.net/ and http://openwetware.org/ to get the materials she needs from http://labx.com/to implement the solution in some gastrointestinal bacteria and cure it herself. Problem freakin’ solved.” [I have no idea whether synthetic biology is as accessible to the masses as this comment would imply (I suspect not). But clearly there is a growing culture of people interested in playing with genetic software and hardware in much the same way as conventional hackers play with computer software and hardware. And this is being spurred on by increasingly easy access to tools and knowledge within a growing grassroots community.

Additional parallels between digital and biological hacking abound. For instance, one of the drivers behind the development of the digital world most of us now inhabit was the open source movement, providing open access to computer code on the understanding that hackers shared any improvements made to the code with the rest of the world. Similar movements are growing up around synthetic biology, with the significant difference being that the “code” is now biological. A good example is the BioBricks Foundation that is developing an open source registry of standard biological parts that can be used to “program living organisms in the same way a computer scientist can program a computer.”

While only time will tell whether the biopunk movement will have the same impact on synbio as the hacker culture had on the digital world (and there are plenty of skeptics out there who are doubtful), the idea of “hacking biology” appeals to plenty of people. Especially where it brings within their grasp tools that enable engineering-based concepts to be applied to biological systems. Drew Endy—a leading proponent of synthetic biology—had this to say in a recent interview:

“Programming DNA is more cool, it’s more appealing, it’s more powerful than silicon. You have an actual living, reproducing machine; it’s nanotechnology that works. It’s not some Drexlarian (Eric Drexler) fantasy. And we get to program it. And it’s actually a pretty cheap technology. You don’t need a FAB Lab like you need for silicon wafers. You grow some stuff up in sugar water with a little bit of nutrients. My read on the world is that there is tremendous pressure that’s just started to be revealed around what heretofore has been extraordinarily limited access to biotechnology.” [While the debate surrounding the social and ethical development and use of synthetic biology tends to focus on issues such as bioterrorism, uncontrolled releases, global justice and the creation of “artificial life,” it is quite possible that a successful biopunk movement will change the context within which this debate is conducted. How do you establish a framework for socially and ethically responsible development when the person you need to reach is an adolescent teenager constructing new biological code in their basement?

This is a major challenge to the development of safe and societally accepted synthetic biology. Biological hacking may never develop on the scale of computer hacking —“life” might shatter our hubris by turning out to be more complex than anyone imagined. But I do not think we can afford to be complacent here. The four recommendations made in the BBSRC report will definitely help pave the way towards socially and ethically responsible synthetic biology: recognizing the importance of maintaining public legitimacy and support; ensuring the scientific community engage with society on the impacts of their work; pursuing partnerships with civil society groups, social scientists and ethicists; and putting in place a robust governance framework before synthetic biology applications are realized. However, I suspect that these are just the first steps in a long process to ensure society as a whole takes responsibility for developing and using an increasing level of control over the basic building blocks of life wisely.

As a final thought, when a hacker causes the digital reality in their computer to malfunction through tinkering, they can simply reboot and start again. It might not be so simple when hacking life itself. This may be a flawed analogy, but it is probably something the new socioethics of synbio should address if serious mis-steps are to be avoided.

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The full August in the Archives 2010 series can be browsed here

Ten emerging technology trends to watch over the next decade

Andrew Maynard — Sat, 26 Dec 2009 00:13:31 +0000

Ten years ago at the close of the 20th century, people the world over were obsessing about the millennium bug – an unanticipated glitch arising from an earlier technology. I wonder how clear it was then that, despite this storm in what turned out to be a rather small teacup, the following decade would see unprecedented advances in technology – the mapping of the human genome, social media, nanotechnology, space-tourism, face transplants, hybrid cars, global communications, digital storage, and more. Looking back, it’s clear that despite a few hiccups, emerging technologies are on a roll – one that’s showing no sign of slowing down.

So what can we expect as we enter the second decade of the twenty first century? What are the emerging technology trends that are going to be hitting the headlines over the next ten years?

Here’s my list of the top ten technologies I think are worth watching. I’m afraid that, as with all crystal ball gazing, it’s bound to be flawed. Yet as I work on the opportunities and challenges of emerging technologies, these do seem to be areas that are ripe for prime time.

Geoengineering

2009 was the year that geoengineering moved from the fringe to the mainstream. The idea of engineering the climate on a global scale has been around for a while. But as the penny has dropped that we may be unable – or unwilling – to curb carbon dioxide emissions sufficiently to manage global warming, geoengineering has risen up the political agenda. My guess is that the next decade will see the debate over geoengineering intensify. Research will lead to increasingly plausible and economically feasible ways to tinker with the environment. At the same time, political and social pressure will grow – both to put plans into action (whether multi- or unilaterally), and to limit the use of geoengineering. The big question is whether globally-coordinated efforts to develop and use the technology in a socially and politically responsible way emerge, or whether we end up with an ugly – and potentially disastrous – free for all.

Smart grids

It may not be that apparent to the average consumer, but the way that electricity is generated, stored and transmitted is under immense strain. As demand for electrical power grows, a radical rethink of the power grid is needed if we are to get electricity to where it is needed, when it is needed. And the solution most likely to emerge as the way forward over the next ten years is the Smart Grid. Smart grids connect producers of electricity to users through an interconnected “intelligent” network. They allow centralized power stations to be augmented with – and even replaced by – distributed sources such as small-scale wind farms and domestic solar panels. They route power from where there is excess being generated to where there is excess demand. And they allow individuals to become providers as well as consumers – feeding power into the grid from home-installed generators, while drawing from the grid when they can’t meet their own demands. The result is a vastly more efficient, responsive and resilient way of generating and supplying electricity. As energy demands and limits on greenhouse gas emissions hit conventional electricity grids over the next decade, expect to see smart grids get increasing attention.

Radical materials

Good as they are, most of the materials we use these days are flawed – they don’t work as well as they could. And usually, the fault lies in how the materials are structured at the atomic and molecular scale. The past decade has seen some amazing advances in our ability to engineer materials with increasing precision at this scale. The result is radical materials – materials that far outperform conventional materials in their strength, lightness, conductivity, ability to transmit heat, and a whole host of other characteristics. Many of these are still at the research stage. But as demands for high performance materials continue to increase everywhere from medical devices to advanced microprocessors and safe, efficient cars to space flight, radical materials will become increasingly common. In particular, watch out for products based on carbon nanotubes. Commercial use of this unique material has had it’s fair share of challenges over the past decade. But I’m anticipating many of these will be overcome over the next ten years, allowing the material to achieve at least some of it’s long-anticipated promise.

Synthetic biology

Ten years ago, few people had heard of the term “synthetic biology.” Now, scientists are able to synthesize the genome of a new organism from scratch, and are on the brink of using it to create a living bacteria. Synthetic biology is about taking control of DNA – the genetic code of life – and engineering it, much in the same way a computer programmer engineers digital code. It’s arisen in part as the cost of reading and synthesizing DNA sequences has plummeted. But it is also being driven by scientists and engineers who believe that living systems can be engineered in the same way as other systems. In many ways, synthetic biology represents the digitization of biology. We can now “upload” genetic sequences into a computer, where they can be manipulated like any other digital data. But we can also “download” them back into reality when we have finished playing with them – creating new genetic code to be inserted into existing – or entirely new – organisms. This is still expensive, and not as simple as many people would like to believe – we’re really just scratching the surface of the rules that govern how genetic code works. But as the cost of DNA sequencing and synthesis continues to fall, expect to see the field advance in huge leaps and bounds over the next decade. I’m not that optimistic about us cracking how the genetic code works in great detail by 2020 – the more we learn at the moment, the more we realize we don’t know. However, I have no doubt that what we do learn will be enough to ensure synthetic biology is a hot topic over the next decade. In particular, look out for synthesis of the first artificial organism, the development and use of “BioBricks” – the biological equivalent of electronic components – and the rise of DIY-biotechnology.

Personal genomics

Closely related to the developments underpinning synthetic biology, personal genomics relies on rapid sequencing and interpretation of an individual’s genetic sequence. The Human Genome Project – completed in 2001 – cost taxpayers around $2.7 billion dollars, and took 13 years to complete. In 2007, James Watson’s genome was sequenced in 2 months, at a cost of $2 million. In 2009, Complete Genomics were sequencing personal genomes at less than $5000 a shot. $1000 personal genomes are now on the cards for the near future – with the possibility of substantially faster/cheaper services by the end of the decade. What exactly people are going to do with all these data is anyone’s guess at this point – especially as we still have a long way to go before we can make sense of huge sections of the human genome. Add to this the complication of epigenetics, where external factors lead to changes in how genetic information is decoded which can pass from generation to generation, and and it’s uncertain how far personal genomics will progress over the next decade. What aren’t in doubt though are the personal, social and economic driving forces behind generating and using this information. These are likely to underpin a growing market for personal genetic information over the next decade – and a growing number of businesses looking to capitalize on the data.

Bio-interfaces

Blurring the boundaries between individuals and machines has long held our fascination. Whether it’s building human-machine hybrids, engineering high performance body parts or interfacing directly with computers, bio-interfaces are the stuff of our wildest dreams and worst nightmares. Fortunately, we’re still a world away from some of the more extreme imaginings of science fiction – we won’t be constructing the prototype of Star Trek Voyager’s Seven of Nine anytime soon. But the sophistication with which we can interface with the human body is fast reaching the point where rapid developments should be anticipated. As a hint of things to come, check out the Luke Arm from Deka (founded by Dean Kamen). Or Honda’s work on Brain Machine Interfaces. Over the next decade, the convergence of technologies like Information Technology, nanoscale engineering, biotechnology and neurotechnology are likely to lead to highly sophisticated bio-interfaces. Expect to see advances in sensors that plug into the brain, prosthetic limbs that are controlled from the brain, and even implants that directly interface with the brain. My guess is that some of the more radical developments in bio-interfaces will probably occur after 2020. But a lot of the groundwork will be laid over the next ten years.

Data interfaces

The amount of information available through the internet has exploded over the past decade. Advances in data storage, transmission and processing have transformed the internet from a geek’s paradise to a supporting pillar of 21st century society. But while the last ten years have been about access to information, I suspect that the next ten will be dominated by how to make sense of it all. Without the means to find what we want in this vast sea of information, we are quite literally drowning in data. And useful as search engines like Google are, they still struggle to separate the meaningful from the meaningless. As a result, my sense is that over the next decade we will see some significant changes in how we interact with the internet. We’re already seeing the beginnings of this in websites like Wolfram Alpha that “computes” answers to queries rather than simply returning search hits, or Microsoft’s Bing, which helps take some of the guesswork out of searches. Then we have ideas like The Sixth Sense project at the MIT Media Lab, which uses an interactive interface to tap into context-relevant web information. As devices like phones, cameras, projectors, TV’s, computers, cars, shopping trolleys, you name it, become increasingly integrated and connected, be prepared to see rapid and radical changes in how we interface with and make sense of the web.

Solar power

Is the next decade going to be the one where solar power fulfills its promise? Quite possibly. Apart from increased political and social pressure to move towards sustainable energy sources, there are a couple of solar technologies that could well deliver over the next few years. The first of these is printable solar cells. They won’t be significantly more efficient than conventional solar cells. But if the technology can be scaled up and some teething difficulties resolved, they could lead to the cost of solar power plummeting. The technology is simple in concept – using relatively conventional printing processes and special inks, solar cells could be printed onto cheap, flexible substrates; roll to roll solar panels at a fraction of the cost of conventional silicon-based units. And this opens the door to widespread use. The second technology to watch is solar-assisted reactors. Combining mirror-concentrated solar radiation with some nifty catalysts, it is becoming increasingly feasible to convert sunlight into other forms of energy at extremely high efficiencies. Imagine being able to split water into hydrogen and oxygen using sunlight and an appropriate catalyst for instance, then recombine them to reclaim the energy on-demand – all at minimal energy loss. Both of these solar technologies are poised to make a big impact over the next decade.

Nootropics

Drugs that enhance mental ability – increasingly referred to as nootropics – are not new. But their use patterns are. Drugs like ritalin, donepezil and modafinil are increasingly being used by students, academics and others to give them a mental edge. What is startling though is a general sense that this is acceptable practice. Back in June I ran a straw poll on 2020 Science to gauge attitudes to using nootropics. Out of 207 respondents, 153 people (74%) either used nootropics, or would consider using them on a regular or occasional basis. In April 2009, an article in the New Yorker reported on the growing use of “neuroenhancing drugs” to enhance performance. And in an informal poll run by Nature in April 2008, 1 in 5 respondents claimed “they had used drugs for non-medical reasons to stimulate their focus, concentration or memory.” Unlike physical performance-enhancing drugs, it seems that the social rules for nootropics are different. There are even some who suggest that it is perhaps unethical not to take them – that operating to the best of our mental ability is a personal social obligation. Of course this leads to a potentially explosive social/technological mix, that won’t be diffused easily. Over the next ten years, I expect the issue of nootropics will become huge. There will be questions on whether people should be free to take these drugs, whether the social advantages outweigh the personal advantages, and whether they confer an unfair advantage to users by leading to higher grades, better jobs, more money. But there’s also the issue of drugs development. If a strong market for nootropics emerges, there is every chance that new, more effective drugs will follow. Then the question arises – who gets the “good” stuff, and who suffers as a result? Whichever way you look at it, the 2010′s are set to be an interesting decade for mind-enhancing substances.

Cosmeceuticals

Cosmetics and pharmaceuticals inhabit very different worlds at the moment. Pharmaceuticals typically treat or prevent disease, while cosmetics simply make you look better. But why keep the two separate? Why not develop products that make you look good by working with your body, rather than simply covering it? The answer is largely due to regulation – drugs have to be put through a far more stringent set of checks and balances that cosmetics before entering the market, and rightly so. But beyond this, there is enormous commercial potential in combining the two, especially as new science is paving the way for externally applied substances to do more than just beautify. Products that blur the line are already available – in the US for instance, sunscreens and anti dandruff shampoos are considered drugs. And the cosmetics industry regularly use the term “cosmeceutical” to describe products with medicinal or drug-like properties. Yet with advances in synthetic chemistry and nanoscale engineering, it’s becoming increasingly possible to develop products that do more than just lead to “cosmetic” changes. Imagine products that make you look younger, fresher, more beautiful, by changing your body rather than just covering up flaws and imperfections. It’s a cosmetics company’s dream – one shared by many of their customers I suspect. The dam that’s preventing many such products at the moment is regulation. But if the pressure becomes too great – and there’s a fair chance it will over the next ten years – this dam is likely to burst. And when it does, cosmeceuticals are going to hit the scene big-time.

So those are my ten emerging technology trends to watch over the next decade. But what happened to nanotechnology, and what other technologies were on my shortlist?

Nanotech has been a dominant emerging technology over the past ten years. But in many ways, it’s a fake. Advances in the science of understanding and manipulating matter at the nanoscale are indisputable, as are the early technology outcomes of this science. But nanotechnology is really just a convenient shorthand for a whole raft of emerging technologies that span semiconductors to sunscreens, and often share nothing more than an engineered structure that is somewhere between 1 – 100 nanometers in scale. So rather than focus on nanotech, I decided to look at specific technologies which I think will make a significant impact over the next decade. Perhaps not surprisingly though, many of them depend in some way on working with matter at nanometer scales.

In terms of the emerging technologies shortlist, it was tough to whittle this down to ten trends. My initial list included batteries, decentralized computing, biofuels, stem cells, cloning, artificial intelligence, robotics, low earth orbit flights, clean tech, neuroscience and memristors – there are many others that no doubt could and should have been on it. Some of these I felt were likely to reach their prime sometime after the next decade. Others I felt didn’t have as much potential to shake things up and make headlines as the ones I chose. But this was a highly subjective and personal process. I’m sure if someone else were writing this, the top ten list would be different.

And one final word. Many of the technologies I’ve highlighted reflect an overarching trend: convergence. Although not a technology in itself, synergistic convergence between different areas of knowledge and expertise will likely dominate emerging technology trends over the next decade. Which means that confident as I am in my predictions, the chances of something completely different, unusual and amazing happening are… pretty high!

Update, 12/27/09 Something’s been bugging me, and I’ve just realized what it is – in my original list of ten, I had smart drugs, but in the editing process they somehow got left by the wayside! As I don’t want to go back and change the ten emerging technology trends I ended up posting, they will have to be a bonus. As it is, drug delivery timelines are so long that I’m not sure how many smart drugs will hit the market before 2020. But when they do, they will surely mark a turning point in therapeutics. These are drugs that are programmed to behave in various ways. The simplest are designed to accumulate around disease sites, then destroy the disease on command – gold shell nanoparticles fit the bill here, preferentially accumulating around tumors then destroying them by heating up when irradiated with infrared radiation. More sophisticated smart drugs are in the pipeline though that are designed to seek out diseased cells, provide local diagnostics, then release therapeutic agents on demand. The result is targeted disease treatment that leads to significantly greater efficacy at substantially lower doses. Whether or not these make a significant impact over the next decade, they are definitely a technology to watch.

Update 12/29/09 Which emerging technologies do you thing will trend over the next decade? Join the discussion on the 2020 Science Facebook page.

A 2020 Science Taster

Andrew Maynard — Thu, 19 Feb 2009 13:00:43 +0000

Given the recent surge in 2020science readers (thanks to Lon S. Cohen at Mashable), I thought it about time I did a short retrospective—a taster for the type of stuff you can expect to read here. So here are five pieces from the past year that cover everything from nanotechnology to synthetic biology, and ethics to the trials of being on the scientific meeting circuit—all from the perspective of emerging technologies.

Enjoy!

Asbestos-like nanomaterials – should we be concerned? It seems that when the possible downsides of nanotechnology are broached, it doesn’t take long for the “A” word to surface. But what is the truth—if any—behind comparisons between nanomaterials and asbestos? From January 2009.

Nanotechnology—In bed with Madonna? How do you squeeze Madonna, John Kerry, nanotechnology and Elle magazine into the same blog? With difficulty is the correct answer I think, but somehow they all managed to appear together in this piece from April 2008.

Synthetic biology, ethics and the hacker culture. What the heck is synthetic biology, is “biopunk” a real word, and are the 21st century equivalents of computer hackers going to reconfigure life as we know it? I can’t promise any easy answers, but hopefully this post from June 2008 helps set the scene.

Geoengineering: Does it need a dose of geoethics? We’ve all heard of bioethics, but if the earth can be treated like one massive complex organism, do we need the planetary equivalent of bioethics—“geoethics” perhaps? From January 2009.

Enough meetings already! Ever get jealous of the scientific jet-set, swanning between “prestigious” speaking engagements in exotic places? Don’t bother—the reality is far from glamorous, as this post from May last year tries to capture. Fortunately, there are occasional compensations, albeit in unlikely forms!

Biohacking—synthetic biology for the technologically marginalized

Andrew Maynard — Sat, 27 Dec 2008 02:41:09 +0000

Last June I wrote a short piece on biohacking, prompted by a UK report on the social and ethical challenges of synthetic biology. At the time, I though the aspirations of the nascent biopunk community naively optimistic, but potentially worrying. Six months on, biohacking is hitting the mainstream press—and gaining momentum.

Maybe it was just a slow news day. Maybe the subject had substance. Either way, a story posted yesterday by the Associated Press on home-style genetic engineering has attracted quite a bit of attention over the new services.

The story revolves around Meredith L. Patterson—a 31-year-old computer programmer who is trying to develop genetically altered yogurt bacteria that glow green to signal the presence of melamine—that most recent of food-contaminants. According to the article, Patterson

“learned about genetic engineering by reading scientific papers and getting tips from online forums. She ordered jellyfish DNA for a green fluorescent protein from a biological supply company for less than $100. And she built her own lab equipment, including a gel electrophoresis chamber, or DNA analyzer, which she constructed for less than $25, versus more than $200 for a low-end off-the-shelf model.”

And if you think that sounds far out, try the group DIYBio for size. Co-founded by Mackenzie Cowell, a 24-year-old who majored in biology in college, the Cambridge Massachusetts group is setting up a community lab where people can use chemicals and lab equipment according to AP—including a used low temperature freezer, scored for free off Craigslist!

The “role models” here seem to be the info-tech underdogs made-good. “Defenders say the future Bill Gates of biotech could be developing a cure for cancer in the garage” notes the AP story, while a piece appearing in the Times Online notes

“Indeed, Apple and Google were created in hobbyists’ garages, and have since gone on to change millions of lives for the better while contributing billions of dollars to the global economy.”

Unfortunately, biotech is not info-tech, although the similarities are seductive—stored information that holds detailed instructions; an ability to re-write this information to control how something behaves; access to increasingly inexpensive tools for manipulating this information; a grass-roots community working outside established institutions; and the possibility of outsiders getting one over the technological elite.

But biotech—and synthetic biology in particular—differs from information technology in a number of critical areas. This is complex stuff—ask any biologist. And it is going to be really tough for a self-trained “biopunk” to assimilate the knowledge and expertise to make a productive contribution to biotechnology. Then, biology is messy. The organic is, quite literally, “organic”—meaning that it resists being ordered and marshaled in the same way as electronic circuits are. And at the end of the day, there is no easy off-switch to living things.

As I wrote back in June,

“when a hacker causes the digital reality in their computer to malfunction through tinkering, they can simply reboot and start again.”

The trouble is, I don’t think that these differences are going to stop the biohacker community growing. And while I have my doubts that the community will produce the Bill Gates of biotech, I do worry that they could cause a lot of harm in trying—you know after all what they say about a little knowledge…

To date, one of the greatest safety concerns over synthetic biology has been dual use—the fear that someone will use it to create a suber-bug (or similar) for malevolent purposes. But my greatest fear is that enthusiastic—and largely uncontrolled—amateurs will create problems out of well-intentioned ignorance. Or more worrying still, they will intentionally develop a disruptive “creation,” just because they can. After all, look at the origins of many computer viruses.

There are some ways in which harmful garage activities could be curbed—suppliers of DNA sequences monitoring who is purchasing what for example. But this is an area that has so far been woefully under-investigated.

A new suite of projects recently announced by the Alfred P. Sloan foundation will hopefully make in-roads into the safe development of synthetic biology. But time is short, the stakes are high, and it’s going to take more than a few foundation grants to get this right.

In the meantime, the Meredith L. Patterson’s of this world are issuing a rallying call to the technologically marginalized—saying you too can play with the big boys and girls at the game of life.

And it won’t be long before they really can…

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Update 12/27/08: for more information on synthetic biology, check out the Synthetic Biology Project at the Wilson Center