On Monday, the National Institute for Occupational Safety released new data on the potential role multi-walled carbon nanotubes play as a cancer-promoter – a substance that promotes the development of cancer in the presence of a carcinogen.  In the study, mice were injected with methylcholanthrene – a cancer initiating agent – and subsequently exposed to airborne multi-walled carbon nanotubes. Compared to a control group, the methylcholanthrene and carbon nanotube-exposed mice were significantly more likely to develop tumors than a control group, developed more tumors, and developed larger tumors.  The study provides a strong indication that this particular form of carbon nanotube material can synergistically increase the likelihood and severity of cancer in the presence of a carcinogen.

The NIOSH research was one of a number of presentations on carbon nanotube safety at this year’s Society of Toxicology meeting.  The results won’t appear in the peer review literature for some time yet, and so it is premature to draw too many conclusions.  However, there is a growing body of research indicating that some forms of carbon nanotubes can present a significant health hazard if used inappropriately.

Unfortunately, there is still considerable uncertainty over which of the many attributes of different carbon nanotubes and nanotube materials are associated with their toxicity, release routes leading to significant exposure, and what constitutes a significant exposure.  These are all areas of extremely high research priority if carbon nanotube material is to be produced, used and disposed of/recycled responsibly.

The carbon nanotubes in this study were inhaled multi-walled carbon nanotubes with a predominantly long, straight fiber-like morphology.  Mice were exposed at a level of 5 mg/m3 for 5 hours per day, over a 15 day period.  From the NIOSH post:

Mice receiving both the initiator chemical plus exposure to MWCNT were significantly more likely to develop tumors (90% incidence) and have more tumors (an average of 3.3 tumors/mouse lung) than mice receiving the initiator chemical alone (50% of mice developing tumors with an average of 1.4 tumors/lung).  Additionally, mice exposed to MWCNT and to MWCNT plus the initiator chemical had larger tumors than the respective control groups.  The number of tumors per animal exposed to MWCNT alone was not significantly elevated compared with the number per animal in the controls.  These results indicate that MWCNT can increase the risk of cancer in mice exposed to a known carcinogen.  The study does not suggest that MWCNTs alone cause cancer in mice.

For further background insight into the complexities of interpreting carbon nanotube toxicity with respect to nanotube exposure and physicochemical characteristics, check out this week’s Risk Bites video:

Additional resources:

NIOSH (2013) New Findings on Lung Tumor Formation in Laboratory Mice Exposed to Multi-Walled Carbon Nanotubes.

Wikipedia: What are carbon nanotubes used for?

Donaldson et al. (2006) Carbon Nanotubes: A Review of Their Properties in Relation to
Pulmonary Toxicology and Workplace Safety.  Toxicol. Sci. 92 (1): 5-22.  [Free download]

Poland et al. (2008) “Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study” Nature Nanotechnology 3, 423 – 428

NIOSH (2010) Occupational Exposure to Carbon Nanotubes and Nanofibers (Draft)

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The World Economic Forum Global Agenda Council on Emerging Technologies has just published its annual list of the top ten emerging technology trends.  Based on expert assessment from council members and others, the list provides insight into technologies that have the potential to have a significant economic and social impact in the near to mid term.

This year’s list includes:

Source: World Economic Forum

OnLine Electric Vehicles (OLEV)

Already widely used to exchange digital information, wireless technology can now also deliver electric power to moving vehicles. In next-generation electric cars, pick-up coil sets under the vehicle floor receive power remotely via an electromagnetic field broadcast from cables installed under the road surface. The current also charges an onboard battery used to power the vehicle when it is out of range. As electricity is supplied externally, these vehicles require only a fifth the battery capacity of a standard electric car, and can achieve transmission efficiencies of over 80 percent. Online electric vehicles are currently undergoing road tests in Seoul, South Korea.

3-D printing and remote manufacturing

Three-dimensional printing allows the creation of solid structures from a digital computer file, potentially revolutionising the economics of manufacturing if objects can be printed remotely in the home or office rather than requiring time and energy for transportation. The process involves layers of material being deposited on top of each other in order to create free-standing structures from the bottom up. Blueprints from computer-aided design are sliced into cross-section for print templates, allowing virtually-created objects to be used as models for ‘hard copies’ made from plastics, metal alloys or other materials.

Self-healing materials

One of the defining characteristics of living organisms is the inherent ability to repair physical damage done to them. A growing trend in biomimicry is the creation of non-living structural materials that also have the capacity to heal themselves when cut, torn or cracked. Self-healing materials which can repair damage without external human intervention could give manufactured goods longer lifetimes and reduce the demand for raw materials, as well as improving the inherent safety of structural materials used in construction or to form the bodies of aircraft.

Energy-efficient water purification

Water scarcity is a worsening ecological problem in many parts of the world due to competing demands from agriculture, cities and other human uses. Where freshwater systems are over-used or exhausted, desalination from the sea offers near-unlimited water but at the expense of considerable use of energy – mostly from fossil fuels – to drive evaporation or reverse osmosis systems. Emerging technologies offer the potential for significantly higher energy efficiency in desalination or purification of wastewater, potentially reducing energy consumption by 50 percent or more. Techniques such as forward osmosis can additionally improve efficiency by utilising low-grade heat from thermal power production or renewable heat produced by solar-thermal geothermal installations.

Carbon dioxide (CO2) conversion and use

Long-promised technologies for the capture and underground sequestration of carbon dioxide have yet to be proven commercially viable, even at the scale of a single large power station. New technologies that convert the unwanted CO2 into saleable goods can potentially address both the economic and energetic shortcomings of conventional CCS strategies. One of the most promising approaches uses biologically-engineered photosynthetic bacteria to turn waste CO2 into liquid fuels or chemicals, in low-cost, modular solar converter systems. Whilst only operational today at the acre scale, individual systems are expected to reach hundreds of acres within as little as two years. Being 10 to 100 times as productive per unit of land area, these systems address one of the main environmental constraints on biofuels from agricultural or algal feedstock, and could supply lower carbon fuels for automobiles, aviation or other large-scale liquid fuel users.

Enhanced nutrition to drive health at the molecular level

Even in developed countries millions of people suffer from malnutrition due to nutrient deficiencies in their diets. Efforts to improve the situation by changing diets have met with limited success.  Now modern genomic techniques have been applied to determine at the gene sequence level the vast number of naturally-consumed proteins which are important in the human diet. The proteins identified may have advantages over standard protein supplements in that they can supply a greater percentage of essential amino acids, and have improved solubility, taste, texture and nutritional characteristics. The large-scale production of pure human dietary proteins based on the application of biotechnology to molecular nutrition can deliver health benefits such as in muscle development, managing diabetes or reducing obesity.

Remote sensing

The increasingly widespread use of sensors that allow often passive responses to external stimulae will continue to change the way we respond to the environment, particularly in the area of health. Examples include sensors that continually monitor bodily function – such as heart rate, blood oxygen and blood sugar levels – and if necessary trigger a medical response such as insulin provision. Advances rely on wireless communication between devices, low power sensing technologies and, sometimes, active energy harvesting.  Other examples include vehicle-to-vehicle sensing for improved safety on the road.

Precise drug delivery through nanoscale engineering

Pharmaceuticals which can be precisely delivered at the molecular level within or around the cell offer unprecedented opportunities for more effectively treatments while reducing unwanted side effects. Targeted nanoparticles that adhere to diseased tissue allow for the micro-scale delivery of potent therapeutic compounds while minimizing their impact on healthy tissue, and are now advancing in medical trials. After almost a decade of research, these new approaches are now finally showing signs of clinical utility, through increasing the local concentration and exposure time of the required drug and thereby increasing its effectiveness. As well as improving the effects of current drugs, these advances in nanomedicine promise to rescue other drugs, which would otherwise be rejected due to their dose-limiting toxicity.

Organic electronics and photovoltaics

Organic electronics – a type of printed electronics – is the use of organic materials such as polymers to create electronic circuits and devices. In contrast to traditional (silicon based) semiconductors that are fabricated with expensive photolithographic techniques, organic electronics can be printed using low-cost, scalable processes such as ink jet printing- making them extremely cheap compared with traditional electronics devices, both in terms of the cost per device and the capital equipment required to produce them. While organic electronics are currently unlikely to compete with silicon in terms of speed and density, they have the potential to provide a significant edge in terms of cost and versatility. The cost implications of printed mass-produced solar photovoltaic collectors for example could accelerate the transition to renewable energy.

Fourth-generation reactors and nuclear waste recycling

Current once-through nuclear power reactors only utilise 1% of the potential energy available in uranium, leaving the rest radioactively contaminated as nuclear ‘waste’. Whilst the technical challenge of geological disposal is manageable, the political challenge of nuclear waste seriously limits the appeal of this zero-carbon and highly scaleable energy technology. Spent-fuel recycling and breeding uranium-238 into new fissile material – known as ‘Nuclear 2.0’ – would extend already-mined uranium resources for centuries while dramatically reducing the volume and long-term toxicity of wastes, whose radioactivity will drop below the level of the original uranium ore on a timescale of centuries rather millennia. This makes geological disposal much less of a challenge (and arguably even unnecessary) and nuclear waste a minor environmental issue compared to hazardous wastes produced by other industries. Fourth-generation technologies, including liquid metal-cooled fast reactors, are now being deployed in several countries and are offered by established nuclear engineering companies.

Links:

Top 10 Emerging Technology Trends for 2013 infographic

World Economic Forum: The Top 10 Emerging Technology Trends for 2013

Washington Post: Top 10 Emerging Technologies for 2013

 

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Cross-posted from Risk Sense

This week’s Risk Bites video takes a roller-coaster ride through some of the hottest topics in risk science.

Admittedly this is a somewhat personal list, and rather constrained by being compressed into a two and a half minute video for a broad audience. But it does touch on some of the more exciting frontier areas in reducing health risk and improving well-being through research and its application.

Here are the five topics that ended up being highlighted:

BIG DATA

Click to watch segment

 

Despite pockets of cynicism over the hype surrounding “big data”, the generation and innovative use of massive amounts of data are transforming how health risks are identified and addressed. With new approaches to data curation, correlation, manipulation and visualization, seemingly disconnected and impenetrable datasets are becoming increasingly valuable tools for shedding new insights into what might cause harm, and how to avoid or reduce it. This is a trend that has been growing for some years, but is now rapidly gaining momentum.

Just four examples of how “big data” is already pushing the boundaries of risk science include:

  • High throughput toxicity screening, where rapid, multiple toxicity assays are changing how the potential hazards of new and existing substances are evaluated;
  • “Omics”, where genomics, proteomics, metabolomics, exposomics and similar fields are shedding new light on the complex biology at the human-environment interface and how this impacts on health and well-being;
  • Risk prediction through the integrated analysis of related datasets; and
  • Designing new chemicals, materials and products to be as safe as possible, by using sophisticated risk data analysis to push risk management up the innovation pipeline.

CLOUD HEALTH, or C-HEALTH

Click to watch segment

 

Hot on the tails of mobile-health, the convergence of small inexpensive sensors, widespread use of smart phones and cloud computing, is poised to revolutionize how risk-relevant data is collected, processed and used to make decisions. Sensors already built into smart phones are already being used to collect basic information on environmental factors that could impact on health – and increasingly sophisticated add-on sensors are becoming more and more available. On their own, these data aren’t that valuable. But with cloud computing it is becoming possible to process and analyze risk-related data from thousands or millions of users – and then provide contributors with personal, near real-time information on potential risks and avoidance strategies. We’re not there yet – but C-Health is on the way!

RESPONSIBLE INNOVATION

Click to watch segment

 

The idea of responsible innovation has been around for some time. The idea is to reduce the potential for future adverse health and environmental impacts by integrating risk management and avoidance strategies into the technology innovation process. And with new technologies emerging at an increasing rate, the social and economic importance of responsible innovation has never been greater. In fields ranging from advanced manufacturing, sophisticated materials and synthetic biology, to 3D printing and remote charging, there is an increasing push to ensure that technological development is informed by the science of risk. And it isn’t only to ensure actual risks are avoided – societal and economic success through responsible innovation also depends on addressing perceived risks.

“HEADOLOGY”

Click to watch segment

 

The psychology and sociology of how individuals and groups make risk-relevant decisions, and the subsequent consequences of these decisions, is a critical component of the science of risk. Just because it is social science rather than natural science does not diminish its importance. In fact, without a sophisticated understanding of how empirical data on hazard, exposure and risk translate into human understanding and action, risk assessment and the science behind it is pretty worthless. But why call this frontier “headology” – which is a made-up word from satirical author Terry Pratchett? Apart from being a little tongue in cheek, I wanted to get away from some of the baggage associated with terms like “risk communication” and “social science”. But whatever you call it, in today’s increasingly connected world, understanding the human element linking data and action on risk is becoming increasingly important.

COMPLEX INTERACTIONS

Click to watch segment

 

This is a bit of a catch-all, but as the “simpler” challenges associated with health risks are resolved (and I use the word “simple” with caution) we are being faced with an ever-growing array of more complex challenges. These include:

  • Exploring and understanding the importance of non-linearity in dose-response relationships – especially at low doses;
  • Getting a better handle on the health-relevance of low level exposures to some substances – especially over long time periods;
  • Better understanding the science behind exposure to synthetic chemicals with hormone-like properties; and
  • Understanding that nature and significance of epigenetic interactions – both within a generation and across generations.

These and similar areas arise from complex interactions between our bodies and the environment we live in – and create for ourselves. The list could be a lot longer, but the bottom line is that some of the knottiest and most significant challenges in risk science involve understanding the positive and adverse impacts of interactions that are not yet well understood.

There are other areas that could have easily made this list – and in all cases these are areas that will continue to remain important well beyond 2013. So feel free to expand on the list in the comments below. And have a great 2013!

 

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Risk Bites – my new foray into the world of YouTube informal education – was officially launched a few weeks ago (although the transition from “unofficial” to “official” simply meant posting new videos more regularly!).  The channel is an experiment in overcoming the tedium and seeming irrelevance of much academic online content by unbundling the things that I research and teach and talking about the interesting stuff in an engaging and accessible way.

Is it working?  It’s too early to say yet.  I’m getting good feedback from my peers.  But I have yet to crack how to get a much wider pool of eyeballs onto the videos (any offers of publicity here gratefully received – the url is http://youtube.com/riskbites – just in case you need it!).  What I’m really looking for is a growing number of subscribers and viewers who are entertained and informed by the videos.

That said, I’m learning a lot from the experience.  The workflow is admittedly crude (idea, script, voice-over, storyboard, film, edit, post – all fit into an already packed schedule).  But that in turn means that the videos can be nearly as responsive as writing a blog post – as last week’s response to the Sandy Hook shootings showed.  In fact, the whole feel of the exercise is very much like the early days of writing posts for 2020 Science.

Filming Risk Bites (click the image to see the video)

The big difference though is the challenge of taking my work on risk and evidence-informed decision-making and dividing it into very short pieces that create a coherent narrative.  A 1 – 2 minute video allows for between 200 – 400 words, which isn’t a whole lot to handle the intricacies of the science of human health risk.  Even seemingly basic concepts like dose-response need a surprising amount of groundwork.  But the beauty of a series of videos like this is that simple self-contained “bites” can be combined to develop a much more complex bigger picture over time.  It’s more like having a conversation with your viewers – albeit a rather drawn out one – than hitting them with the full weight of risk science all at once (intellectually satisfying to the lecturer, but terrifying for everyone else!).

Brave new territory for me.  But quite exhilarating.  And a lot of fun!

All I need now is as many subscribers as I can scarf up.

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A guest post by Candace Rowell MPH. Candace is an alum of the University of Michigan School of Public Health Department of Environmental Health Sciences, and a former contributor to Mind The Science Gap.  She is currently a research associated with the Qatar Environment and Energy Research Institute in Doha, Qatar.

The traffic in Doha is horrendous. Ask anyone who lives here. It might take you 45 minutes to commute a mere 15 km. The summers are brutal – the temperature bounces around the 50⁰C mark and the humidity threatens to drown you on the doorstep.

Yes, this is Doha; [click to continue…]

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Open access academics: Experiments with YouTube, the Science of Risk, and Professional Amateurism

by Andrew Maynard October 14, 2012

YouTube intrigues me.  Having been dragged into the YouTube culture by my teenagers over the past two years, I’ve been fascinated by the shift from seemingly banal content to a sophisticated social medium. But what has really grabbed my attention is the growth of YouTube as a unique and powerful platform for informal education which [...]

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Why should I wash my hands if I only pee?

by Andrew Maynard September 24, 2012

Cross-posted from Risk Sense “Why should I wash my hands if I only pee?” It’s the sort of question most parents have had to handle at some time – especially if you have pretentious kids who delight in telling you how pure pee is! It’s also the subject of the first post in this semester’s [...]

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Jumping the gap between a US and UK high school education

by Andrew Maynard July 29, 2012

Tomorrow, my 16 year old daughter is leaving her home in the US for the UK. She’ll be there for the next two years while she studies for her A levels.  It was a heart-rending decision for my wife and I to agree to her living apart from us in a different country.  But the [...]

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“We took a rat apart and rebuilt it as a jellyfish”

by Andrew Maynard July 22, 2012

Sometimes you read a science article and it sends a shiver tingle down your spine.  That was my reaction this afternoon reading Ed Yong’s piece on a paper just published in Nature Biotechnology by Janna Nawroth, Kevin Kit Parker and colleagues. The gist of the work is that Parker’s team have created a hybrid biological [...]

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Social Media and the art of Academic Juggling

by Andrew Maynard July 19, 2012

It had to happen – despite deluding myself that I could squeeze everything into a 140 hour work week, something’s going to have to give.  And that something is going to be regular posts on 2020 Science.  I’ll still be posting here, just not as frequently.  Chairing a department, directing a center, teaching, research, doing [...]

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YouTube does the the Higgs Boson – Science communication on the quick!

by Andrew Maynard July 5, 2012

Hot on the heels of yesterday’s announcement on the Higgs Boson, some of YouTube’s most viewed science communicators have been burning the midnight oil to explain why this is so exciting.  Wrapping up this series of posts on YouTube, I thought I would call out three prominent YouTubers who were at VidCon this last week, [...]

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VidCon 2012: Online learning is where online music was five years ago

by Andrew Maynard June 30, 2012

YouTube is gearing up to transform the way we learn.  At least that’s the message that came across loud and clear at this morning’s VidCon breakout panel on education. In an overflowing room of well over two hundred conference goers, head of YouTube Education Angela Lin led a panel of five leading video makers in [...]

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VidCon 2012: Community-grown science communicators smoking’ it!

by Andrew Maynard June 29, 2012

I‘m over half way through the first day at VidCon 2012, and thought I would jot a few notes down on the science scene here.  OK, so maybe 7,000 people haven’t come to the Anaheim Convention Center to hear the latest on the Higgs boson and other interesting science stuff (although you’d be surprised by [...]

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VidCon and YouTube Science

by Andrew Maynard June 19, 2012

Having been initiated into the alternative world of teen YouTube culture last year, I am once again being dragged along to VidCon – the Comic-Con of the online video community.  This year – the third year for VidCon – promises to be bigger than better than ever with around 6,000 signed up for a two [...]

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Top ten reasons professors become chairs!

by Andrew Maynard June 13, 2012

A good colleague sent these to me the other day – I think I’m #1, but I wouldn’t rule out #7! Top Ten Reasons Professors Become Chairs* 10.  Because you don’t want someone else to do it, even though you don’t. 9.  Because you’re burned out teaching the same thing over and over again for [...]

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Fool for a year!

by Andrew Maynard May 31, 2012

Fool!  At least that was what came out of my wife’s mouth as we were discussing my latest failure to say “no!”  In this case, it was a request to take over as Interim Chair of the University of Michigan School of Public Health Environmental Health Sciences Department. You know that feeling where volunteers are [...]

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Communicating about communicating science at the National Academies

by Andrew Maynard May 22, 2012

I‘ve just spent the last two days at the National Academies of Science listening to a long strong of folks talk about the Science of Science Communication.  It was a bit of a guilty pleasure for me as I wasn’t a speaker and so could just kick back and listen – but I did get [...]

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Think Design – an alternative take on nanotech (in 11 minutes!)

by Andrew Maynard May 22, 2012

A few weeks ago I was asked to give a “TED style talk” on nanotechnology for the University of Michigan Environmental Health Sciences department 125th anniversary.  What they got was a short talk on “thinking small”: The other talks in the series are also worth checking out – covering topics as diverse as epigenetics, cancer, [...]

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Carbon nanoparticles could be ubiquitous to many foods

by Andrew Maynard May 19, 2012

TEM images of carbon particles from foods containing caramelized sugar. Click to see larger image. Source: Palashudding et al. Nanotechnology leads to novel materials, new exposures and potentially unique health and environmental risks – or so the argument goes.  But an increasing body of research is showing that relatively uniformly sized nanometer scale particles are [...]

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New journal on Environment, Systems and Decisions looking for contributions

by Andrew Maynard May 15, 2012

Call me a fool, but I recently agree to join the editorial board of the new Springer journal Environment, Systems and Decisions (formerly The Environmentalist).  Actually it was a bit of a no-brainer – I’ve been looking for a journal to get involved with that more closely matched my interests in risk, technology innovation and [...]

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